2. Gene
  3. Wee1 - WEE 1 homolog 1 (S. pombe) Gene

Wee1 - WEE 1 homolog 1 (S. pombe) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：WEE 1 同系物 1 (S. pombe)

种属: Mus musculus

同用名: Wee1A

基因 ID: 22390 | 基因类型: protein coding

关于 Wee1

Chromosome 7: 109,721,253-109,742,493 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 227 orthologues, 8 paralogues and is associated with 19 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 12.3), placenta adult (RPKM 11.4) and 27 other tissues.

功能概要

该基因编码的蛋白可启动蛋白激酶活性。在几个过程的上游或内部起作用，包括建立细胞极性；神经元投射形态发生；和肽基酪氨酸磷酸化。位于细胞质中。以多种结构表达，包括 8 细胞期胚胎；消化系统；胚泡;脑室层；和下丘。与人类 WEE1（WEE1 G2 检查点激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Acts upstream of or within several processes, including establishment of cell polarity; neuron projection morphogenesis; and peptidyl-tyrosine phosphorylation. Located in cytoplasm. Is expressed in several structures, including 8-cell stage embryo; alimentary system; blastocyst; brain ventricular layer; and inferior colliculus. Orthologous to human Wee1 (Wee1 G2 checkpoint kinase). [provided by Alliance of Genome Resources, Apr 2022]

Wee1 基因产物(2)

mRNA Protein Name
NM_001355058.1 NP_001341987.1 wee1-like protein kinase isoform 2
NM_009516.3 NP_033542.2 wee1-like protein kinase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20026642 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
7551544 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within establishment of cell polarity IMP
IMP: 通过突变表型推断
20026642 MGI
acts upstream of or within microtubule cytoskeleton organization IMP
IMP: 通过突变表型推断
20026642 MGI
acts upstream of or within neuron projection morphogenesis IGI
IGI: 通过遗传相互作用推断
20026642 MGI
acts upstream of or within neuron projection morphogenesis IMP
IMP: 通过突变表型推断
20026642 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
15459478 MGI
acts upstream of or within protein phosphorylation IDA
IDA: 通过直接分析推断
7551544 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15459478 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Wee1 蛋白结构

PTKc_Wee1a

PTKc_Wee1a: cd14138 (291 - 566)

  • 0
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  • 200
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  • 400
  • 500
  • 600
  • 646 a.a.
蛋白主名 其他名称

wee1-like protein kinase

WEE1 tyrosine kinase

wee1A kinase

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17583 Griseofulvin 99.07% 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-10993 Adavosertib Inhibitor 99.96% Phase 2
HY-145817A lunresertib Inhibitor 99.97% Phase 2
Pre-clinical Phase
生物活性分子 (67)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132295 Azenosertib Inhibitor 99.96% 否
HY-13925 PD0166285 Inhibitor 99.46% 否
HY-147054 Zedoresertib Inhibitor 99.85% 否
HY-175749 BMS-986463 Degrader 98.63% 否
HY-122113 PD173952 Inhibitor 99.44% 否
HY-N0819 Raddeanin A Inhibitor 98.55% 否
HY-18961 PD 407824 Inhibitor 99.00% 否
HY-133618 Pomalidomide-C3-adavosertib Degrader 99.84% 否
HY-148065 FMF-06-098-1 Inhibitor 98.77% 否
HY-147312 GSK-1520489A Inhibitor 99.83% 否
HY-108343 WEE1-IN-4 Inhibitor 99.70% 否
HY-148062 RSS0680 99.85% 否
HY-145817 (Rac)-lunresertib Inhibitor 99.72% 否
HY-103029 Bosutinib isomer Inhibitor 99.62% 否
HY-138239 WEE1-IN-3 Inhibitor 98.64% 否
HY-W1135319 SB-405483 99.33% 否
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% 否
HY-144999 LEB-03-146 98.08% 否
HY-161880 WEE1-IN-10 Inhibitor 99.32% 否
HY-173320 HEMTAC WEE1 degrader-1 Degrader 99.78% 否
HY-145817B (R)-lunresertib Inhibitor 99.87% 否
HY-163697 WEE1-IN-7 Inhibitor 99.70% 否
HY-145666 Myt1-IN-3 Inhibitor 99.14% 否
HY-145664 Myt1-IN-1 Inhibitor 98.97% 否
HY-169946 WEE1/PKMYT1-IN-1 Inhibitor 98.84% 否
HY-W070306 PDK1-IN-1 Inhibitor 99.95% 否
HY-168654 WEE1 degrader 1 Degrader 99.74% 否
HY-163490 PKMYT1-IN-1 Inhibitor 99.24% 否
HY-145665 Myt1-IN-2 Inhibitor / 否
HY-182906 XL495 Inhibitor / 否
HY-180893 XH-30 Inhibitor / 否
HY-163491 PKMYT1-IN-2 Inhibitor / 否
HY-175819 PD-166285 Inhibitor / 否
HY-180484 PKMYT1-IN-12 Inhibitor / 否
HY-178190 WEE1-IN-13 Inhibitor / 否
HY-176957 PKMYT1-IN-11 Inhibitor / 否
HY-176283 Tubulin/LSD1-IN-1 Inhibitor / 否
HY-182791 BAA-009 Inhibitor / 否
HY-178150 WEE1-IN-14 Inhibitor / 否
HY-143343 LEB-03-153 / 否
HY-161879 WEE1-IN-9 Inhibitor / 否
HY-180485 PROTAC D16-M1P2 Degrader / 否
HY-13925A PD0166285 dihydrochloride Inhibitor / 否
HY-182790 BAA-065 Inhibitor / 否
HY-169946B WEE1/PKMYT1-IN-3 Inhibitor / 否
HY-169946A WEE1/PKMYT1-IN-2 Inhibitor / 否
HY-143342 LEB-03-144 / 否
HY-161871 WEE1-IN-8 Inhibitor / 否
HY-176363 Adavosertib-C3-NH-Boc Inhibitor / 否
HY-172807 p38α-IN-9 Inhibitor / 否
HY-168180 WEE1-IN-11 Inhibitor / 否
HY-179272 Wee1/HDAC-IN-1 Inhibitor / 否
HY-175817 PKMYT1-IN-10 Inhibitor / 否
HY-157443 Myt1-IN-4 Inhibitor / 否
HY-160948 DB07006 Inhibitor / 否
HY-133703A i-AZD1775 TFA Inhibitor / 否
HY-143340 LEB-03-145 / 否
HY-160530 WEE1-IN-6 Inhibitor / 否
HY-172759 PKMYT1-IN-9 Inhibitor / 否
HY-174448 WEE1-IN-12 Inhibitor / 否
HY-162849 PKMYT1-IN-3 Inhibitor / 否
HY-175261 DHI1 Inhibitor / 否
HY-162988 Myt1-IN-5 Inhibitor / 否
HY-162986 PKMYT1-IN-4 Inhibitor / 否
HY-159937 PKMYT1-IN-7 Inhibitor / 否
HY-162987 PKMYT1-IN-6 Inhibitor / 否
HY-176853 Myt1-IN-6 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Wee1 NCBI NCBI:7465
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