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By Research Areas:	Cancer (3765) Cardiovascular Disease (98) Endocrinology (77) Infection (136) Inflammation/Immunology (404) Metabolic Disease (183) Neurological Disease (451)
Click Chemistry:	叠氮化物 (80) 炔烃 (46) PROTAC合成 (16) 四嗪 (1) ADC合成 (2) 二苯并环辛炔 (3) 双环[6,1,0]壬炔 (22) 标记与荧光成像 (9)
Oligonucleotides:	趋化因子 (28) 反义寡核苷酸 (2) PEG化脂质 (17) 小干扰RNA (1) 磷脂 (4) CpG寡核苷酸 (9) 核酸适配体 (3) mRNA (41) siRNA drugs (1) 佐剂 (2) 胆固醇 (2) 阳离子脂质 (3)

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Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates PD-1/PD-L1

Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-103597

Thalidomide-O-COOH 2 篇文献验证 Cereblon Ligand 3; E3 ligase Ligand 3	Ligands for E3 Ligase	Cancer
Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的，可募集 CRBN 蛋白的 Cereblon 配体。Thalidomide-O-COOH (Cereblon ligand 3) 可通过 linker 与靶蛋白配体连接，形成 PROTAC 分子。

HY-175686

*E3 ligase Ligand* 67**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 67 (Compound 5) 是一种 STUB1/CHIP 配体，在荧光偏振分析中对于 CHIP 的 K_d 为 8.9 μM。KLHDC2 ligand 1 是一种 E3 连接酶配体 (E3 ligase ligand)。KLHDC2 ligand 1 可用于合成 PROTACs。

HY-174982

*YTHDF2 ligand-1*	YTHDF	Cancer
YTHDF2 ligand-1 (Compound 23) 是一种选择性和高亲和力的 YTHDF2 配体，K_d 为 1.3 μM (FP 检测) 和 IC₅₀ 为 11 μM (HTRF检测)。YTHDF2 ligand-1 可用于肿瘤的研究。

HY-75578

*dTAG Targeting Ligand* 1**	Polo-like Kinase (PLK) Ligands for Target Protein for PROTAC	Cancer
dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) 是一种 PROTAC 靶蛋白配体 (Ligand for Target Protein for PROTAC)。dTAG Targeting Ligand 1 可用于合成 PROTACs。

HY-161830

*CDK7 ligand* 2**	Ligands for Target Protein for PROTAC	Cancer
CDK7 ligand 2 (Compound A6) 是一种 CDK7 配体。CDK7 ligand 2 可用于 PROTACs 的合成。

HY-W037495

*DCAF15 ligand-1*	Ligands for E3 Ligase	Cancer
DCAF15 ligand-1 (compound 9) 是 E3 连接酶 DCAF15 的配体。DCAF15 ligand-1 可用于合成 IBG1 (HY-153459)。

HY-133045

*VHL Ligand* 8**	Ligands for E3 Ligase	Cancer
VHL Ligand 8 是一种 von Hippel-Lindau (VHL) 蛋白配体。VHL Ligand 8 可用于合成 ARD-266 (HY-133020)。ARD-266 是一种高效且基于 VHL E3 连接酶的雄激素受体 (AR) PROTAC 降解剂。ARD-266 有效诱导 AR 阳性 LNCaP，VCaP 和 22Rv1 前列腺癌细胞系中的 AR 蛋白降解，DC₅₀ 值为 0.2-1 nM。

HY-150407

*TSPO ligand-1*	Ligands for Target Protein for PROTAC Autophagy	Others Neurological Disease Cancer
TSPO ligand-1 是 AUTAC4 (HY-134640) 的配体，可用于合成 PROTACs。TSPO ligand-1 是一种线粒体外膜跨膜结构域蛋白，可与 AUTAC4 相结合，调节线粒体自噬 (autophagy) 促进靶向线粒体更新。TSPO ligand-1 也可参与胆固醇从线粒体外膜到内膜的转运，作为脑损伤和神经变性的敏感生物标志物。

HY-161537

*EGFR ligand-9*	EGFR	Cancer
EGFR ligand-9 是 EGFR 配体。EGFR ligand-9 可用于合成 PROTAC EGFR degrader 9 (HY-161536).

HY-168685

*c-Myc ligand* 1**	c-Myc Ligands for Target Protein for PROTAC	Cancer
c-Myc ligand 1 是一种 c-Myc 抑制剂，是 PROTAC 靶蛋白配体 (Ligand for Target Protein for PROTAC)。c-Myc ligand 1 可用于合成 PROTAC c-Myc inhibitor 7 (HY-148837)。

HY-168683

*CDK8 ligand* 1**	Ligands for Target Protein for PROTAC CDK	Cancer
CDK8 ligand 1 是 CDK8 的配体。CDK8 ligand 1 可用于合成 LL-K8-22 (HY-149209)。

HY-150839

*E3 ligase Ligand* PG**	Ligands for E3 Ligase	Cancer
E3 ligase Ligand PG 是一种可用于募集 CRBN 蛋白的 E3 连接酶配体 (E3 ligase ligand)。E3 ligase Ligand PG 与 CRBN 表现出强效结合活性（IC₅₀ 为 2.191 μM）。E3 ligase Ligand PG 可通过 linker 与 BMS-202（HY-19745）连接形成 PROTAC，PROTAC PD-L1 degrader-1 (HY-163757)。

HY-161575

*NSD2 ligand* 1**	Histone Methyltransferase Ligands for Target Protein for PROTAC	Cancer
NSD2 ligand 1 是 NSD2 配体。NSD2 ligand 1 可用于合成 LLC0424 (HY-161574) (PROTAC NSD2 降解剂)。

HY-47709

*STING ligand-3*	Ligands for Target Protein for PROTAC	Inflammation/Immunology
STING ligand-3 是 PROTAC 的靶蛋白配体 (Ligand for Target Protein for PROTAC) 活性对照。STING ligand-3 可用于合成 Anti-inflammatory agent 70 (HY-157570)。

HY-W733888

*CRBN ligand-187*	Ligands for E3 Ligase	Cancer
CRBN ligand-187 是一种可用于合成 TQ-3959 (HY-175541) 的 CRBN 型 E3 泛素连接酶配体。

HY-173562

*PRMT5 ligand* 2**	Ligands for Target Protein for PROTAC	Cancer
PRMT5 ligand 2 (Compound 38) 是一种 PROTAC 靶蛋白配体 (Ligands for Target Protein for PROTACs)。PRMT5 ligand 2 可用于合成 MS115 (HY-173561)。

HY-145484

*PROTAC IRAK4 ligand-3*	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-3 是可用于组成 PROTAC KT-474 (HY-145483) 的靶蛋白配体，可用于癌症的研究。

HY-W342590

*CRBN ligand-9*	Ligands for E3 Ligase	Cancer
CRBN ligand-9 (Compound 4d) 是一种 CRBN 配体 (K_i: 8.9 μM)。CRBN ligand-9 可用于 PROTACs 的合成。

HY-161829

*CDK7 ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
CDK7 ligand 1 是 CDK7 ligand 2 (HY-161830) 的活性对照配体。CDK7 ligand 2 是一种 CDK7 配体。CDK7 ligand 2 可用于 PROTACs 的合成。

HY-W754809

*ALK ligand-1*	Ligands for Target Protein for PROTAC Anaplastic lymphoma kinase (ALK)	Cancer
ALK ligand-1 是一种 ALK 配体，可用于合成 PROTAC ALK degrader-4 (HY-175527)。

HY-168302

*BTK ligand* 10**	Ligands for Target Protein for PROTAC Tyrosinase Btk	Cancer
BTK ligand 10 是 BTK 的配体。BTK ligand 10 可用于合成 NX-2127 (HY-153220)。

HY-175526

*Aurora kinase ligand-1*	Ligands for Target Protein for PROTAC Aurora Kinase	Cancer
Aurora kinase ligand-1 (Compound I-4) 是一种极光激酶 B (AURKB) PROTAC 配体。Aurora kinase ligand-1 可与 E3 连接酶配体 (HY-112078) 和连接子偶联合成 AURKB PROTAC 降解剂 MS44 (HY-175525)。MS44 可用于癌症研究。

HY-176367

*Multi kinase ligand* 4**	Ligands for Target Protein for PROTAC	Cancer
Multi kinase ligand 4 是一种靶蛋白配体，可用于合成 PROTAC DB-0646 (HY-137343)。

HY-179051

*PSMA ligand* 3**	Ligands for Target Protein for PROTAC PSMA	Cancer
PSMA ligand 3 是 Psa-AR (HY-179056) 的一种 PSMA 靶向配体。Psa-AR 可用于癌症研究。

HY-176334

*TBK1 ligand* 2**	Ligands for Target Protein for PROTAC IKK	Cancer
TBK1 ligand 2 (Compound 1b) 是一种 TBK1 抑制剂。TBK1 ligand 2 可用于合成 PROTAC TBK1 degrader-2 (HY-112557)。

HY-W128709

*SNAP-fusion protein ligand-1*	Others	Others
SNAP-fusion protein ligand-1 (Compound 3) 是一种 PROTAC 的靶蛋白配体 (Ligand for Target Protein for PROTAC)。SNAP-fusion protein ligand-1 可用于合成 PROTAC VHL-SNAP2-5C (HY-175417)。

HY-168449

*BAZ2A/B ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
BAZ2A/B ligand 1 (compound 1) 是 PROTAC 靶蛋白配体 (Ligand for Target Protein for PROTAC)。BAZ2A/B ligand 1 可用于合成 dBAZ2 (HY-168448)。

HY-158771

*PRC1 ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
PRC1 ligand 1 是 MS147 (HY-160924) 的靶蛋白配体。PRC1 ligand 1 可用于研究癌症。

HY-175449

*XIAP ligand* 5**	Ligands for E3 Ligase IAP	Others
XIAP ligand 5 是一种 XIAP 拮抗剂。XIAP ligand 5 是一种 E3 连接酶配体 (E3 ligase ligand)。XIAP ligand 5 可用于合成 PROTAC GNE-1567 (HY-175448)。

HY-171774

*PBRM1/SMARCA2,4-ligand-1*	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Cancer
PBRM1/SMARCA2,4-ligand-1 (Compound 4) 是与 PBRM1、SMARCA2 和 SMARCA4 结合的 PROTAC 靶蛋白配体。PBRM1/SMARCA2,4-ligand-1 是一种有效的 SMARCA4 溴结构域抑制剂。PBRM1/SMARCA2,4-ligand-1 可用于合成 PROTAC AU-24118 (HY-163410)。

HY-174218

*KLHDC2 ligand* 1**	Ligands for E3 Ligase	Cancer
KLHDC2 ligand 1 是一种 E3 连接酶配体 (E3 ligase ligand)。KLHDC2 ligand 1 可用于合成 PROTAC BRD4 Degrader-31 (HY-174210)。

HY-44824

*SMARCA2 ligand-13*	Ligands for Target Protein for PROTAC SWI/SNF Complex	Cancer
SMARCA2 ligand-13 是 PROTAC 靶蛋白配体 (Ligand for Target Protein for PROTAC)。SMARCA2 ligand-13 可用于合成 PROTAC。

HY-150905

*EGFR ligand-2*	EGFR	Cancer
EGFR ligand-2 (compound C4) 是一种共价 EGFR 配体，是一种 EGFR 突变抑制剂，对 EGFR^L858R 和 EGFR^L858R/T790M 的 IC₅₀ 分别为 21 nM 和 48 nM。EGFR ligand-2 可用于合成 PROTAC。

HY-168299

*AR ligand-30*	Androgen Receptor Ligands for Target Protein for PROTAC	Cancer
AR ligand-30 是 PROTAC Bavdegalutamide (HY-138641) 的靶蛋白配体，可用于前列腺癌研究。

HY-174878

*BCL-xL ligand* 2**	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
BCL-xL ligand 2 是一种 BCL-xL 的配体。BCL-xL ligand 2 可以与 E3 连接酶配体 (HY-138793) 和 linker 偶联合成 Bcl-xL 的 PROTAC 靶向降解剂PZ671 (HY-174876)。

HY-176183

*STING ligand-4*	Ligands for Target Protein for PROTAC STING	Inflammation/Immunology
STING ligand-4 (Compound 2) 是一种无硝基共价 STING 抑制剂，IC₅₀ < 0.2 μM。STING ligand-4 可用于合成 PROTAC STING degrader-4 (HY-176180)。

HY-175371

*RIPK1-ligand-2*	RIP kinase Ligands for Target Protein for PROTAC	Cancer
RIPK1-ligand-2 是一种 RIPK1 抑制剂。RIPK1-ligand-2 可用于合成 PROTAC RIPK1 Degrader-1 (HY-175370)。

HY-178035

*OSBP ligand-1*	Oxysterol-binding Protein-related Protein (ORP) Ligands for Target Protein for PROTAC	Cancer
OSBP ligand-1 (Compound 2) 是一种氧固醇结合蛋白 (OSBP) 抑制剂。OSBP ligand-1 可用于合成 PROTAC OSBP Degrader-1 (HY-178034)。

HY-175242

*PROTAC BRD4 ligand-4*	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Others
PROTAC BRD4 ligand-4 是一种 BRD4 配体，可用于合成 PROTAC BRD4 Degrader-37 (HY-175225).

HY-174857

*HBeAg ligand* 1**	Ligands for Target Protein for PROTAC HBV	Infection
HBeAg ligand 1 (Compound S2) 是一种 HBeAg 抑制剂。HBeAg ligand 1 可用于合成 PROTAC HBeAg degrader-1 (HY-174856)。

HY-174352

*TERT ligand-1*	Ligands for Target Protein for PROTAC Telomerase	Cancer
TERT ligand-1 是一种 PROTAC 靶蛋白配体，可用于合成 PROTAC NU-PRO-1 (HY-174351)。NU-PRO-1 能在癌细胞中诱导 TERT 降解。

HY-168611

*PROTAC IRAK4 ligand-4*	Ligands for Target Protein for PROTAC IRAK	Cancer
PROTAC IRAK4 ligand-4 是 PROTAC 的靶蛋白配体 (Ligand for Target Protein for PROTAC)，具有抗肿瘤活性。PROTAC IRAK4 ligand-4 可用于合成 PROTAC IRAK4 degrader-12 (HY-168586)。

HY-174408

*HDAC6 ligand-5*	Ligands for Target Protein for PROTAC HDAC	Cancer
HDAC6 ligand-5 是 HDAC6 的结合配体，可用于合成 PROTACs 比如PROTAC HDAC6 degrader 5 (HY-174401)。

HY-174812

*BRD4 ligand* 8**	Ligands for Target Protein for PROTAC Epigenetic Reader Domain	Inflammation/Immunology Cancer
BRD4 ligand 8 (Compound J558) 是一种 BRD4 抑制剂。BRD4 ligand 8 可用于合成 PROTAC BRD4 Degrader-33 (HY-174811)。

HY-P99133

*Anti-Mouse Fas Ligand* Antibody (MFL3)**	TNF Receptor	Inflammation/Immunology Cancer
Anti-Mouse Fas Ligand Antibody (MFL3) 是一种抗小鼠 Fas Ligand 的 IgG 抗体抑制剂，来源于亚美尼亚仓鼠。Anti-Mouse Fas Ligand Antibody (MFL3) 能够阻断 Fas 配体 (FasL)。Anti-Mouse Fas Ligand Antibody (MFL3) 可用于癌症和免疫学研究。

HY-179294

*POI ligand-2*	Ligands for Target Protein for PROTAC Glutathione Peroxidase	Cancer
POI ligand-2 是 GPX4 蛋白的配体。POI ligand-2 可用于合成 PROTAC，如 PROTAC GPX4 degrader-5 (HY-178925)。

HY-170996

*ROR1 ligand-1*	ROR	Cancer
ROR1 ligand-1 (9-1) 是 PROTAC ROR1 降解剂-1 (HY-170995) 的配体。ROR1 ligand-1 通过与 VHL型或 CRBN 配体连接，设计并合成了首个选择性且高效的 ROR1 PROTAC 分子。

HY-161598

*DYRK2 ligand* 1**	Ligands for Target Protein for PROTAC	Cancer
DYRK2 ligand 1 是 PROTAC DYRK2 degrader 1 (HY-161597) 的靶蛋白配体。DYRK2 ligand 1 可用于研究癌症。

HY-170861

*E3 ligase Ligand* 58**	Ligands for E3 Ligase	Others
E3 ligase Ligand 58 是一种 E3 连接酶配体 (E3 ligase ligand)。E3 ligase Ligand 58 可用于合成 PROTAC AH078 (HY-170859)。

HY-172740

*BCL6 ligand-3*	Ligands for Target Protein for PROTAC	Cancer
BCL6 ligand-3 是一种 PROTAC 靶蛋白配体 (Ligands for Target Protein for PROTACs)。BCL6 ligand-3 可以作为 BMS-986458 (HY-172736) 靶蛋白配体的活性对照。