人高密度脂蛋白
High density lipoprotein (human) 是一种人源高密度脂蛋白。High density lipoprotein 可穿过血脑屏障，通过激活 SR-B1、S1P3R 等表面受体，以及涉及 Akt、PI3K 和 MAPK 的细胞内信号级联反应，部分作用于内皮型一氧化氮合酶 (eNOS)，从而在内皮细胞中诱导 NO 的生成。High density lipoprotein (human) 可用于 2 型糖尿病、阿尔茨海默病、癌症及动脉粥样硬化的相关研究。
3-Indolepropionic acid (Standard) 是 3-Indolepropionic acid 的分析标准品。本产品用于研究及分析应用。3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Cochinchinenin C 是一种 GLP-1R 激动剂，可通过疏水作用和氢键结合受体胞外域，促进胰腺 β 细胞的葡萄糖依赖性胰岛素分泌。Cochinchinenin C 还提高细胞内 cAMP 和 ATP 水平。Cochinchinenin C 在低浓度下能结合人血清白蛋白，改变其微环境并引发显性静态荧光猝灭。Cochinchinenin C 对胰腺 β 细胞几乎无细胞毒性，且在结合人血清白蛋白时与 Loureirin A (HY-N1505) 具有协同作用。Cochinchinenin C 已被广泛应用于 2 型糖尿病、幽门螺杆菌感染及血栓性疾病等研究。
莱苞迪甙 A (标准品)
Rebaudioside A (Standard) 是 Rebaudioside A 的分析标准品。本产品用于研究及分析应用。Rebaudioside A 是一种口服有效的甜菊醇糖苷，具有较高的甜味。Rebaudioside A 是 α-glucosidase 抑制剂，IC50 值是 35.01 μg/mL。Rebaudioside A 通过葡萄糖依赖性的方式，增加 β 细胞内的 ATP/ADP 比值，从而抑制 KATP 通道，导致细胞膜去极化、钙离子内流，最终刺激胰岛素分泌。Rebaudioside A 通过抑制胆固醇合成的限速酶 HMGCR，激活 SREBP 信号通路，导致细胞表面 LDLR 表达增加，从而促进血液中 LDL-C 的摄取。Rebaudioside A 可用于研究血糖、血脂调节和抗肥胖。
糖尿病是以长期高血糖为特征的代谢疾病。主要有两种类型：I 型糖尿病（T1D）和 II 型糖尿病（T2D）。I 型糖尿病又称为青少年糖尿病或胰岛素依赖型糖尿病，是以胰腺中 β 细胞破坏，不能产生胰岛素为特征；而 II 型糖尿病又称为非胰岛素依赖性糖尿病，其特征为胰岛素分泌进行性障碍，靶组织对分泌的胰岛素敏感性降低，其中 II 型糖尿病是糖尿病中的主要形式。所有类型的糖尿病都可能导致身体许多部位出现并发症，并增加过早死亡的风险，可能的并发症包括肾功能衰竭、截肢、视力丧失和神经损伤等。
人高密度脂蛋白
High density lipoprotein (human) 是一种人源高密度脂蛋白。High density lipoprotein 可穿过血脑屏障，通过激活 SR-B1、S1P3R 等表面受体，以及涉及 Akt、PI3K 和 MAPK 的细胞内信号级联反应，部分作用于内皮型一氧化氮合酶 (eNOS)，从而在内皮细胞中诱导 NO 的生成。High density lipoprotein (human) 可用于 2 型糖尿病、阿尔茨海默病、癌症及动脉粥样硬化的相关研究。
3-Indolepropionic acid (Standard) 是 3-Indolepropionic acid 的分析标准品。本产品用于研究及分析应用。3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.
Cochinchinenin C 是一种 GLP-1R 激动剂，可通过疏水作用和氢键结合受体胞外域，促进胰腺 β 细胞的葡萄糖依赖性胰岛素分泌。Cochinchinenin C 还提高细胞内 cAMP 和 ATP 水平。Cochinchinenin C 在低浓度下能结合人血清白蛋白，改变其微环境并引发显性静态荧光猝灭。Cochinchinenin C 对胰腺 β 细胞几乎无细胞毒性，且在结合人血清白蛋白时与 Loureirin A (HY-N1505) 具有协同作用。Cochinchinenin C 已被广泛应用于 2 型糖尿病、幽门螺杆菌感染及血栓性疾病等研究。
莱苞迪甙 A (标准品)
Rebaudioside A (Standard) 是 Rebaudioside A 的分析标准品。本产品用于研究及分析应用。Rebaudioside A 是一种口服有效的甜菊醇糖苷，具有较高的甜味。Rebaudioside A 是 α-glucosidase 抑制剂，IC50 值是 35.01 μg/mL。Rebaudioside A 通过葡萄糖依赖性的方式，增加 β 细胞内的 ATP/ADP 比值，从而抑制 KATP 通道，导致细胞膜去极化、钙离子内流，最终刺激胰岛素分泌。Rebaudioside A 通过抑制胆固醇合成的限速酶 HMGCR，激活 SREBP 信号通路，导致细胞表面 LDLR 表达增加，从而促进血液中 LDL-C 的摄取。Rebaudioside A 可用于研究血糖、血脂调节和抗肥胖。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
