核糖核酸酶A
RNase A (Bovine pancreatic RNase) 是一种广泛用于 DNA 纯化的核酸内切酶 (Endonuclease)，它能特异性水解 RNA 中的胞嘧啶或尿嘧啶残基。RNase A 可降解 RNA/DNA 双链体中的 RNA。RNase A 催化单链 RNA 的 3',5'-磷酸二酯键断裂。生物体内的 RNase A 家族成员与多种生理和病理过程密切相关，包括细胞生长发育、增殖、分化和迁移。RNase A 活性或表达水平的失调与胰腺癌、卵巢癌、膀胱癌和甲状腺癌密切相关。RNase A 具有杀伤肿瘤细胞的能力。
脱氧核糖核酸酶 I (过滤)
DNase I 是一种降解 DNA 的酶。DNase I 主要由消化系统器官产生，例如胰腺和腮腺。已知哺乳动物有三种类型的 DNase I：胰腺型、腮腺型和胰腮腺型。DNase I 在细胞外 DNA 的裂解中起着关键作用, 对限制炎症反应和维持体内平衡至关重要。DNase I 负责消化细胞外核蛋白，这对于预防自身免疫反应可能至关重要。DNase I 活性降低可能与系统性红斑狼疮 (SLE) 的发生发展有关。DNase I (filtered) 通过 0.22 μM 滤膜过滤，未进行热原性测试。
重组核糖核酸酶A (无动物源)
RNase A (Bovine pancreatic RNase) 是一种广泛用于 DNA 纯化的核酸内切酶 (Endonuclease)，它能特异性水解 RNA 中的胞嘧啶或尿嘧啶残基。RNase A 可降解 RNA/DNA 双链体中的 RNA。RNase A 催化单链 RNA 的 3',5'-磷酸二酯键断裂。生物体内的 RNase A 家族成员与多种生理和病理过程密切相关，包括细胞生长发育、增殖、分化和迁移。RNase A 活性或表达水平的失调与胰腺癌、卵巢癌、膀胱癌和甲状腺癌密切相关。RNase A 具有杀伤肿瘤细胞的能力。RNase A, Recombinant (animal free) 是重组 RNase A，无动物源性成分。
脱氧核糖核酸酶 I (不含RNase & 蛋白酶)
DNase I 是一种降解 DNA 的酶。DNase I 主要由消化系统器官产生，例如胰腺和腮腺。已知哺乳动物有三种类型的 DNase I：胰腺型、腮腺型和胰腮腺型。DNase I 在细胞外 DNA 的裂解中起着关键作用, 对限制炎症反应和维持体内平衡至关重要。DNase I 负责消化细胞外核蛋白，这对于预防自身免疫反应可能至关重要。DNase I 活性降低可能与系统性红斑狼疮 (SLE) 的发生发展有关。DNase I (RNase & Protease free) 是分子生物学等级，通过色谱纯化去除 RNase 和蛋白酶的 DNase I。
核糖核酸酶 A, 重组
RNase A (Bovine pancreatic RNase) 是一种广泛用于 DNA 纯化的核酸内切酶 (Endonuclease)，它能特异性水解 RNA 中的胞嘧啶或尿嘧啶残基。RNase A 可降解 RNA/DNA 双链体中的 RNA。RNase A 催化单链 RNA 的 3',5'-磷酸二酯键断裂。生物体内的 RNase A 家族成员与多种生理和病理过程密切相关，包括细胞生长发育、增殖、分化和迁移。RNase A 活性或表达水平的失调与胰腺癌、卵巢癌、膀胱癌和甲状腺癌密切相关。RNase A 具有杀伤肿瘤细胞的能力。RNase A, Recombinant (Ribonuclease A, Recombinant) 是重组的 RNase A。
核糖核酸酶 A (不含 DNase 和蛋白酶), 重组
RNase A (Bovine pancreatic RNase) 是一种广泛用于 DNA 纯化的核酸内切酶 (Endonuclease)，它能特异性水解 RNA 中的胞嘧啶或尿嘧啶残基。RNase A 可降解 RNA/DNA 双链体中的 RNA。RNase A 催化单链 RNA 的 3',5'-磷酸二酯键断裂。生物体内的 RNase A 家族成员与多种生理和病理过程密切相关，包括细胞生长发育、增殖、分化和迁移。RNase A 活性或表达水平的失调与胰腺癌、卵巢癌、膀胱癌和甲状腺癌密切相关。RNase A 具有杀伤肿瘤细胞的能力。RNase A (DNase & Protease Free), Recombinant 是重组的 RNase A，不含 DNase 和蛋白酶。
RNase A (Bovine pancreatic RNase) 是一种广泛用于 DNA 纯化的核酸内切酶 (Endonuclease)，它能特异性水解 RNA 中的胞嘧啶或尿嘧啶残基。RNase A 可降解 RNA/DNA 双链体中的 RNA。RNase A 催化单链 RNA 的 3',5'-磷酸二酯键断裂。生物体内的 RNase A 家族成员与多种生理和病理过程密切相关，包括细胞生长发育、增殖、分化和迁移。RNase A 活性或表达水平的失调与胰腺癌、卵巢癌、膀胱癌和甲状腺癌密切相关。RNase A 具有杀伤肿瘤细胞的能力。RNase A, Bovine Pancreas (DNase & Protease Free) 是牛胰腺来源 RNase A，不含 DNase 和蛋白酶。
Salvicine 是一种 DNA 拓扑异构酶 II (Topo II) 抑制剂 (IC50=3 μM)。Salvicine 通过与 ATP 酶结构域相互作用，增加 DNA 与 Topo II 的相互作用，抑制 DNA 的降解和 ATP 的水解。Salvicine 具有抗癌活性，包括抑制 Topo II、造成 DNA 损伤、克服多药耐药性和抑制肿瘤细胞粘附等。
GNE-274 是 ER 降解剂 GDC-0927 的结构类似物，是一种非降解剂。GNE-274 在乳腺癌细胞系中不诱导 ER 的转换，作为 ER 的部分激动剂 (partial ER agonist) 发挥作用。GNE-274 增加了ER-DNA 结合位点的的染色质可进入性，而 GDC-0927 则没有。GNE-274 是一种有效的 ER 配体结合域 (LBD) 抑制剂。GNE-274 可用于癌症研究。
原卟啉IX
Protoporphyrin IX 是血红素生物合成途径中的最终中间体。Protoporphyrin IX 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX 在给药 5-aminolevulinic acid (5-ALA) (HY-W000450) 后在大鼠肿瘤细胞中形成和积累。当激活峰值波长为 405 nm 的红色荧光时，Protoporphyrin IX 引起基底细胞癌的选择性改善。Protoporphyrin IX 有望用于声动力和光动力对癌症的药物研究，如膀胱癌和结节性基底细胞癌。
原卟啉 IX (二钠)
Protoporphyrin IX disodium 是血红素生物合成途径中的最终中间体。Protoporphyrin IX disodium 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX disodium 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX disodium 在给药 5-aminolevulinic acid (5-ALA) (HY-W000450) 后在大鼠肿瘤细胞中形成和积累。当激活峰值波长为 405 nm 的红色荧光时，Protoporphyrin IX disodium 引起基底细胞癌的选择性改善。Protoporphyrin IX disodium 有望用于声动力和光动力对癌症的药物研究，如膀胱癌和结节性基底细胞癌。
原卟啉IX (标准品)
Protoporphyrin IX (Standard)是 Protoporphyrin IX 的分析标准品。本产品用于研究及分析应用。Protoporphyrin IX 是血红素生物合成途径中的最终中间体。Protoporphyrin IX 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX 在给药 5-aminolevulinic acid (5-ALA) (H
原卟啉IX
Protoporphyrin IX 是血红素生物合成途径中的最终中间体。Protoporphyrin IX 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX 在给药 5-aminolevulinic acid (5-ALA) (HY-W000450) 后在大鼠肿瘤细胞中形成和积累。当激活峰值波长为 405 nm 的红色荧光时，Protoporphyrin IX 引起基底细胞癌的选择性改善。Protoporphyrin IX 有望用于声动力和光动力对癌症的药物研究，如膀胱癌和结节性基底细胞癌。
原卟啉IX (标准品)
Protoporphyrin IX (Standard)是 Protoporphyrin IX 的分析标准品。本产品用于研究及分析应用。Protoporphyrin IX 是血红素生物合成途径中的最终中间体。Protoporphyrin IX 作为辐射敏化剂，即使在缺氧状态下也能增强 ROS 的生成并诱导 DNA 损伤。Protoporphyrin IX 也作为光敏剂，通过光照射直接降解发生光漂白。Protoporphyrin IX 在给药 5-aminolevulinic acid (5-ALA) (H
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
