Aristolactam I 是一种 AQP1 抑制剂和 Aristolochic acid I 代谢产物。Aristolactam I 可从马兜铃属植物中分离得到。Aristolactam I 可下调 Twist1 表达，增加 E-cadherin 表达，并激活 TGF-β/Smad 信号通路。Aristolactam I 具有抗乳腺癌活性。Aristolactam I 具有肾毒性。Aristolactam I 主要用于乳腺癌和肾间质纤维化等肾脏疾病的研究。
多黏菌素 B
Polymyxin B 是一种抗生素 (antibiotic)。Polymyxin B 通过与细菌 (bacterial) 壁的 LPS 高亲和力结合去抑制革兰氏阴性菌 (Gram-negative) 感染。Polymyxin B 可以中和内毒素的效果。Polymyxin B 通过增加其渗透性诱导细菌死亡。Polymyxin B 可用于内毒素血症研究。
丹酚酸 D
Salvianolic acid D 是一种 Depside。Salvianolic acid D 可从 Salvia miltiorrhiza、Danshen 中分离得到。Salvianolic acid D 促进 Bcl-2 的表达，并抑制 Bax、以及 Cleaved caspase-3 和 -9 的表达。Salvianolic acid D 在体内和体外均降低 TLR4、MyD88 和 TRAF6 蛋白的表达强度，并显著抑制 NF-κB 核转位。Salvianolic acid D 抑制 HMGB1 的胞质转位。Salvianolic acid D 抑制炎症反应、减轻脑缺血再灌注损伤。Salvianolic acid D 可作为潜在的抗血小板活性成分。
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 是一种具有心血管活性的神经肽 Y (NPY) 片段类似物。[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 在高血压和正常血压大鼠上均能诱导深刻的、持续性的低血压，其降压效应部分归因于其对组胺受体 (Histamine Receptor) 的活性。[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 可用于研究降血压。
Roridin E 是一种葡萄糖-6-磷酸酶 (G6Pase) 抑制剂和抗生素，是 Roridin A (HY-N9599) 的代谢副产物。Roridin E 会引发显著的氧化应激反应，表现为消耗体内谷胱甘肽、诱导肝脏脂质过氧化以及抑制肾脏超氧化物歧化酶活性。Roridin E 能够降低大鼠血糖水平，但具有急性毒性 (与亚油酸 (HY-N0729) 联用时毒性增强)，并会导致雄性白化小鼠出现肝毒性。Roridin E 可诱导血液总蛋白降低以及总脂质、γ-谷氨酰转移酶、碱性磷酸酶和 5'-核苷酸酶水平升高。Roridin E 能够从霉菌中分离得到，具有与 Verrucarin A (HY-107426) 和 Roridin A 相似的细胞抑制和真菌抑制活性。Roridin E 在啮齿类动物中具有体内活性，常被用于肝毒性相关研究。
Kalopanaxsaponin H 是一种常春藤皂苷元糖苷 (皂苷)，无腹腔注射降糖活性。Kalopanaxsaponin H 可被人体肠道细菌代谢为 Kalopanaxsaponin I、Kalopanaxsaponin A、常春藤皂苷元 3-O-α-L-阿拉伯吡喃糖苷和常春藤皂苷元，其中 Kalopanaxsaponin I 和常春藤皂苷元为主要代谢产物。Kalopanaxsaponin H 可从刺楸 (Kalopanax pictus) 的茎皮中分离得到，并用于糖尿病相关研究。
[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 是一种具有心血管活性的神经肽 Y (NPY) 片段类似物。[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 在高血压和正常血压大鼠上均能诱导深刻的、持续性的低血压，其降压效应部分归因于其对组胺受体 (Histamine Receptor) 的活性。[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat 可用于研究降血压。
Aristolactam I 是一种 AQP1 抑制剂和 Aristolochic acid I 代谢产物。Aristolactam I 可从马兜铃属植物中分离得到。Aristolactam I 可下调 Twist1 表达，增加 E-cadherin 表达，并激活 TGF-β/Smad 信号通路。Aristolactam I 具有抗乳腺癌活性。Aristolactam I 具有肾毒性。Aristolactam I 主要用于乳腺癌和肾间质纤维化等肾脏疾病的研究。
Roridin E 是一种葡萄糖-6-磷酸酶 (G6Pase) 抑制剂和抗生素，是 Roridin A (HY-N9599) 的代谢副产物。Roridin E 会引发显著的氧化应激反应，表现为消耗体内谷胱甘肽、诱导肝脏脂质过氧化以及抑制肾脏超氧化物歧化酶活性。Roridin E 能够降低大鼠血糖水平，但具有急性毒性 (与亚油酸 (HY-N0729) 联用时毒性增强)，并会导致雄性白化小鼠出现肝毒性。Roridin E 可诱导血液总蛋白降低以及总脂质、γ-谷氨酰转移酶、碱性磷酸酶和 5'-核苷酸酶水平升高。Roridin E 能够从霉菌中分离得到，具有与 Verrucarin A (HY-107426) 和 Roridin A 相似的细胞抑制和真菌抑制活性。Roridin E 在啮齿类动物中具有体内活性，常被用于肝毒性相关研究。
丹酚酸 D
Salvianolic acid D 是一种 Depside。Salvianolic acid D 可从 Salvia miltiorrhiza、Danshen 中分离得到。Salvianolic acid D 促进 Bcl-2 的表达，并抑制 Bax、以及 Cleaved caspase-3 和 -9 的表达。Salvianolic acid D 在体内和体外均降低 TLR4、MyD88 和 TRAF6 蛋白的表达强度，并显著抑制 NF-κB 核转位。Salvianolic acid D 抑制 HMGB1 的胞质转位。Salvianolic acid D 抑制炎症反应、减轻脑缺血再灌注损伤。Salvianolic acid D 可作为潜在的抗血小板活性成分。
Kalopanaxsaponin H 是一种常春藤皂苷元糖苷 (皂苷)，无腹腔注射降糖活性。Kalopanaxsaponin H 可被人体肠道细菌代谢为 Kalopanaxsaponin I、Kalopanaxsaponin A、常春藤皂苷元 3-O-α-L-阿拉伯吡喃糖苷和常春藤皂苷元，其中 Kalopanaxsaponin I 和常春藤皂苷元为主要代谢产物。Kalopanaxsaponin H 可从刺楸 (Kalopanax pictus) 的茎皮中分离得到，并用于糖尿病相关研究。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
![[D-Tyr27,36, D-Thr32]-Neuropeptide Y (27-36), rat](http://hg.y866.cn/biomolecule/lib/file/product_pic/hy-p11411.gif)
![Dibenz[a,h]anthracene](http://hg.y866.cn/biomolecule/lib/file/product_pic/hy-w013053.gif)
