Endonuclease IV 是一种脱嘌呤/脱嘧啶 (AP) 核酸内切酶,是一种 DNA 修复酶。Endonuclease IV 具有 AP 位点的核酸内切酶活性、3' 磷酸二酯酶活性 (可去除 DNA 3' 端的各种连接阻断损伤)、针对氧化性 DNA 损伤的核酸内切酶活性以及 3' 至 5' 外切酶活性。
A2G2F2 glycan (A2G2F2(a1-3) glycan) 是包含两个 Lewis X 表位的 Lewis X 多糖,是对称的 N-聚糖。SLeX 是细胞粘附分子 E-选择素 (E-selectin) 的配体,E-选择素在炎症病变部位特异性表达。设计 SLeX-多糖的偶联物,可以将药物递送至炎症病灶。
甲苯胺蓝O
Toluidine Blue (Toluidine Blue O) 是一种碱性的醌亚胺染料 (活体染料),对酸性组织成分有很高的亲和力,可将细胞核染成蓝色,多糖染成紫色。Toluidine Blue 对肥大细胞、粘蛋白和软骨细胞显示异染性。Toluidine Blue 可使植物组织和细胞的不同成分染成不同的颜色。Toluidine Blue 还可作为辅助诊断工具,鉴别恶性病变,如癌症。
Toluidine Blue (Toluidine Blue O) purity 36% 是一种碱性的醌亚胺染料 (活体染料),对酸性组织成分有很高的亲和力,可将细胞核染成蓝色,多糖染成紫色。Toluidine Blue purity 36% 对肥大细胞、粘蛋白和软骨细胞显示异染性。Toluidine Blue purity 36% 可使植物组织和细胞的不同成分染成不同的颜色。Toluidine Blue purity 36% 还可作为辅助诊断工具,鉴别恶性病变,如癌症。
胶原酶VI
Collagenase, Type VI (EC 3.4.24.3) 是胶原酶,可以降解 VI 型胶原蛋白。VI 型胶原蛋白是各种组织 (如皮肤、心脏、血管、软骨和滑液中的细胞膜成分),胶原酶过量会导致细胞外基质病变。胶原酶也是肿瘤侵袭和转移的生物标志物。Collagenase, Type VI 能够特异性作用于脯氨酸和甘氨酸之间的肽键,利用这一特点,能够用对应修饰的电极在实验中快速、灵敏地检测其浓度水平。
四氮唑红
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) 是一种不易穿透大脑的无色水溶性染料,主要在活细胞的线粒体中被线粒体酶还原成深红色的,不溶于水的化合物 (甲臜)。Tetrazolium Red 用于观察脱氢酶的活性,暴露于氢气时会由无色变为红色。Tetrazolium Red 能区分中风后存活和坏死的脑组织。Tetrazolium Red 还被用于染色心脏组织,以测量急性损伤的程度,也用于染色脑组织以检测缺血区域的大小。Tetrazolium Red 吸收波长 570 nm。
Carbendazim mixture with flusilazole是一种用于防治Botrytis narcissicola引起的烟煤病的杀菌剂。在英国,这种疾病是水仙(Narcissus cultivars)最常见的叶部疾病,会导致球茎和花产量显著损失。研究发现,Carbendazim mixture with flusilazole与其他几种杀菌剂一起使用时,能够有效减少病斑大小,并在喷洒后显著减少次生烟煤病的症状。在剑桥郡和林肯郡的田间试验中,采用这种混合杀菌剂的喷洒程序对控制烟煤病效果显著。此外,使用不同作用方式的两种或三种杀菌剂交替喷洒四到六次,不仅能够减少病害,还能提高球茎产量。研究讨论了选择合适的杀菌剂以及可能减少喷洒次数的控制方法。
番茄皂苷元
Esculeogenin A 是番茄皂苷 Esculeoside A (HY-N18067) 的皂苷元。Esculeogenin A 是一种具有口服活性的保肝、降血脂和抗氧化剂。Esculeogenin A 可调控 PPARα、SREBP1、Nrf2、NF-κB、ACAT1/ACAT2 等分子靶点,从而促进肝脏脂肪酸氧化、抑制从头脂生成、增强抗氧化防御并抑制炎症反应。Esculeogenin A 可改善肝功能、缓解高脂血症、抑制肝脂肪变性和泡沫细胞形成,能够预防高脂饮食喂养大鼠的非酒精性脂肪肝病,并减少 apoE 缺陷小鼠的动脉粥样硬化病变。Esculeogenin A 可用于非酒精性脂肪肝病、动脉粥样硬化和高脂血症的相关研究。
Toluidine Blue (Toluidine Blue O) purity 36% 是一种碱性的醌亚胺染料 (活体染料),对酸性组织成分有很高的亲和力,可将细胞核染成蓝色,多糖染成紫色。Toluidine Blue purity 36% 对肥大细胞、粘蛋白和软骨细胞显示异染性。Toluidine Blue purity 36% 可使植物组织和细胞的不同成分染成不同的颜色。Toluidine Blue purity 36% 还可作为辅助诊断工具,鉴别恶性病变,如癌症。
四氮唑红
Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) 是一种不易穿透大脑的无色水溶性染料,主要在活细胞的线粒体中被线粒体酶还原成深红色的,不溶于水的化合物 (甲臜)。Tetrazolium Red 用于观察脱氢酶的活性,暴露于氢气时会由无色变为红色。Tetrazolium Red 能区分中风后存活和坏死的脑组织。Tetrazolium Red 还被用于染色心脏组织,以测量急性损伤的程度,也用于染色脑组织以检测缺血区域的大小。Tetrazolium Red 吸收波长 570 nm。
A2G2F2 glycan (A2G2F2(a1-3) glycan) 是包含两个 Lewis X 表位的 Lewis X 多糖,是对称的 N-聚糖。SLeX 是细胞粘附分子 E-选择素 (E-selectin) 的配体,E-选择素在炎症病变部位特异性表达。设计 SLeX-多糖的偶联物,可以将药物递送至炎症病灶。
番茄皂苷元
Esculeogenin A 是番茄皂苷 Esculeoside A (HY-N18067) 的皂苷元。Esculeogenin A 是一种具有口服活性的保肝、降血脂和抗氧化剂。Esculeogenin A 可调控 PPARα、SREBP1、Nrf2、NF-κB、ACAT1/ACAT2 等分子靶点,从而促进肝脏脂肪酸氧化、抑制从头脂生成、增强抗氧化防御并抑制炎症反应。Esculeogenin A 可改善肝功能、缓解高脂血症、抑制肝脂肪变性和泡沫细胞形成,能够预防高脂饮食喂养大鼠的非酒精性脂肪肝病,并减少 apoE 缺陷小鼠的动脉粥样硬化病变。Esculeogenin A 可用于非酒精性脂肪肝病、动脉粥样硬化和高脂血症的相关研究。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.