常春藤苷C
Hederacoside C (Kalopanaxsaponin B) 是一种可从常春藤叶子中主得到的成分。Hederacoside C 通过抑制 MAPK/NF-κB 及其下游信号通路的激活介导炎症反应。Hederacoside C 具有抗炎和抗菌 (antibacterial) 活性。
鸦胆子素A
Bruceine A (Dihydrobrusatol) 是一种天然的苦木素。Bruceine A 是一种寄生虫 (parasites)，NF-κB，和 PFKFB4 (Kd: 44 nM) 抑制剂。Bruceine A 是一种 P38α MAPK 激活剂。Bruceine A 具有抗寄生虫活性。Bruceine A 具有抗肿瘤活性并抑制癌细胞迁移。Bruceine A 可阻断细胞周期并诱导细胞凋亡 (apoptosis)。Bruceine A 可用于寄生虫、胰腺癌和乳腺癌的研究。
白头翁皂苷A
Pulchinenoside A (Anemoside A3) 是一种具有口服活性的三萜糖苷，被发现存在于白头翁 (Pulsatilla chinensis) 的根中。Pulchinenoside A 具有抗炎、抗肿瘤、抗抑郁、免疫调节和神经保护作用。Pulchinenoside A 可激活 NF-κB/MAPK 信号通路。Pulchinenoside A 可诱导大鼠肾动脉产生舒张作用。Pulchinenoside A 可用于实验性自身免疫性脑脊髓炎、乳腺癌、抑郁症及肾血管性高血压的相关研究。
Cudraflavone B 是一种异戊二烯化类黄酮，具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的双重抑制剂。Cudraflavone B 阻断巨噬细胞中 核因子 κB (NF-κB) 从细胞质到细胞核的易位。由此，Cudraflavone B 也抑制肿瘤坏死因子 α (TNFα) 的基因表达和分泌。Cudraflavone B 还触发线粒体凋亡通路，激活 NF-κB、MAPK p38 和 ERK，并诱导 SIRT1 的表达。由此，Cudraflavone B 抑制人口腔鳞状细胞癌细胞的生长。
3-脱氧苏木酮 B
Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用，可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERK MAPK 途径的信号通路，抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。
常春藤苷C (标准品)
Hederacoside C (Standard) 是 Hederacoside C 的分析标准品。本产品用于研究及分析应用。Hederacoside C (Kalopanaxsaponin B) 是一种可从常春藤叶子中主得到的成分。Hederacoside C 通过抑制 MAPK/NF-κB 及其下游信号通路的激活介导炎症反应。Hederacoside C 具有抗炎和抗菌 (antibacterial) 活性。
Ephemeranthol A 是一种菲类化合物，具有抗癌和抗炎活性。Ephemeranthol A 通过抑制 NF-κB 和 MAPK 信号通路，在巨噬细胞中发挥显著的抗炎作用。Ephemeranthol A 通过抑制 FAK/Akt 信号和 EMT 过程，诱导肺癌细胞凋亡 (apoptosis) 和抑制转移。Ephemeranthol A 可用于急慢性炎症疾病和非小细胞肺癌的研究。
Calebin A 是一种具有口服活性的 PI3K/Akt/mTOR、MAPK 和 NF-κB 抑制剂。Calebin A 可阻断自噬抑制作用，抑制细胞凋亡。Calebin A 可通过表观遗传调控发挥抗肿瘤活性。Calebin A 可抑制脂肪生成、调节产热并富集肠道益生菌。Calebin A 可用于骨关节炎、阿尔茨海默病、2 型糖尿病、恶性外周神经鞘瘤及结直肠癌的相关研究。
土贝母苷甲
Tubeimoside I 是一种口服活性的 HSPD1 抑制剂。Tubeimoside I 能够抑制 NF-κB 和 MAPK，调节 eNOS-VEGF。Tubeimoside I 通过 Akt 介导通路诱导细胞保护性自噬 (Autophagy)。Tubeimoside I 抑制促炎细胞因子 (IL-6 和 IL-1β) 产生。Tubeimoside I 具有抗炎活性，能够促进血管生成，改善脓毒症症状。Tubeimoside I 主要用于炎症性疾病、各种癌症、脓毒症和缺血性疾病的研究。
Murrayafoline A (Standard) 是 Murrayafoline A (HY-W100287) 的分析标准品。本产品用于研究及分析应用。Murrayafoline A 是一种可以从 Murraya tetramera 中提取的咔唑类生物碱。Murrayafoline A 直接靶向特异性蛋白 1 (Sp1)，从而抑制 NF-κB 和 MAPK 信号通路。Murrayafoline A 在血小板衍生生长因子 (PDGF) 刺激的血管平
冬绿苷 (标准品)
Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654).
土贝母苷甲 (标准品)
Tubeimoside I (Standard) 是 Tubeimoside I 的分析标准品。本产品用于研究及分析应用。Tubeimoside I 是一种口服活性的 HSPD1 抑制剂。Tubeimoside I 能够抑制 NF-κB 和 MAPK，调节 eNOS-VEGF。Tubeimoside I 通过 Akt 介导通路诱导细胞保护性自噬 (Autophagy)。Tubeimoside I 抑制促炎细胞因子 (IL-6 和 IL-1β) 产生。Tubeimoside I 具有抗炎活性，能够促进血管生成，改善脓毒症症状。Tubeimoside I 主要用于炎症性疾病、各种癌症、脓毒症和缺血性疾病的研究。
黄卡瓦胡椒素B
Flavokawain B (Flavokavain B) 是一种口服活性的查耳酮。Flavokawain B 可激活 caspase-9、-3 和 -8，切割 PARP。Flavokawain B 可下调 Bcl-2，同时增加 Bax 水平。Flavokawain B 可抑制 NF-κB、PI3K/Akt 和 MAPK 信号通路。Flavokawain B 具有凋亡 (Apoptotic) 作用。Flavokawain B 可抑制 MMP-9 和促进 ROS 生成。Flavokawain B 可抑制多种肿瘤和炎症。
Murrayafoline A 是一种可以从 Murraya tetramera 中提取的咔唑类生物碱。Murrayafoline A 直接靶向特异性蛋白 1 (Sp1)，从而抑制 NF-κB 和 MAPK 信号通路。Murrayafoline A 在血小板衍生生长因子 (PDGF) 刺激的血管平滑肌细胞中诱导 G0/G1 期阻滞。Murrayafoline A 通过促进细胞内 β-catenin 的降解减弱 Wnt/β-catenin 途径。Murrayafoline A 通过激活蛋白激酶 C 增强大鼠心室肌细胞的收缩和 L 型钙电流。Murrayafoline A 抑制体内 LPS (HY-D1056) 诱导的神经炎症。Murrayafoline A 可用于炎症、血管并发症和结肠癌研究。
常春藤苷C
Hederacoside C (Kalopanaxsaponin B) 是一种可从常春藤叶子中主得到的成分。Hederacoside C 通过抑制 MAPK/NF-κB 及其下游信号通路的激活介导炎症反应。Hederacoside C 具有抗炎和抗菌 (antibacterial) 活性。
鸦胆子素A
Bruceine A (Dihydrobrusatol) 是一种天然的苦木素。Bruceine A 是一种寄生虫 (parasites)，NF-κB，和 PFKFB4 (Kd: 44 nM) 抑制剂。Bruceine A 是一种 P38α MAPK 激活剂。Bruceine A 具有抗寄生虫活性。Bruceine A 具有抗肿瘤活性并抑制癌细胞迁移。Bruceine A 可阻断细胞周期并诱导细胞凋亡 (apoptosis)。Bruceine A 可用于寄生虫、胰腺癌和乳腺癌的研究。
白头翁皂苷A
Pulchinenoside A (Anemoside A3) 是一种具有口服活性的三萜糖苷，被发现存在于白头翁 (Pulsatilla chinensis) 的根中。Pulchinenoside A 具有抗炎、抗肿瘤、抗抑郁、免疫调节和神经保护作用。Pulchinenoside A 可激活 NF-κB/MAPK 信号通路。Pulchinenoside A 可诱导大鼠肾动脉产生舒张作用。Pulchinenoside A 可用于实验性自身免疫性脑脊髓炎、乳腺癌、抑郁症及肾血管性高血压的相关研究。
Cudraflavone B 是一种异戊二烯化类黄酮，具有抗炎和抗癌特性。Cudraflavone B 也是 COX-1 和 COX-2 的双重抑制剂。Cudraflavone B 阻断巨噬细胞中 核因子 κB (NF-κB) 从细胞质到细胞核的易位。由此，Cudraflavone B 也抑制肿瘤坏死因子 α (TNFα) 的基因表达和分泌。Cudraflavone B 还触发线粒体凋亡通路，激活 NF-κB、MAPK p38 和 ERK，并诱导 SIRT1 的表达。由此，Cudraflavone B 抑制人口腔鳞状细胞癌细胞的生长。
3-脱氧苏木酮 B
Deoxysappanone B (3-Deoxysappanone B) 是一种从 Caesalpinia sappan L (Lignum Sappan) 分离得到的异黄酮化合物。Deoxysappanone B 具有抗神经炎症和神经保护作用，可以通过阻断 IκB kinase (IKK)-NF-κB 和 p38/ERK MAPK 途径的信号通路，抑制神经炎症介质的产生。Deoxysappanone B 可用于神经炎和炎症相关的神经损伤的疾病研究。
常春藤苷C (标准品)
Hederacoside C (Standard) 是 Hederacoside C 的分析标准品。本产品用于研究及分析应用。Hederacoside C (Kalopanaxsaponin B) 是一种可从常春藤叶子中主得到的成分。Hederacoside C 通过抑制 MAPK/NF-κB 及其下游信号通路的激活介导炎症反应。Hederacoside C 具有抗炎和抗菌 (antibacterial) 活性。
Ephemeranthol A 是一种菲类化合物，具有抗癌和抗炎活性。Ephemeranthol A 通过抑制 NF-κB 和 MAPK 信号通路，在巨噬细胞中发挥显著的抗炎作用。Ephemeranthol A 通过抑制 FAK/Akt 信号和 EMT 过程，诱导肺癌细胞凋亡 (apoptosis) 和抑制转移。Ephemeranthol A 可用于急慢性炎症疾病和非小细胞肺癌的研究。
Calebin A 是一种具有口服活性的 PI3K/Akt/mTOR、MAPK 和 NF-κB 抑制剂。Calebin A 可阻断自噬抑制作用，抑制细胞凋亡。Calebin A 可通过表观遗传调控发挥抗肿瘤活性。Calebin A 可抑制脂肪生成、调节产热并富集肠道益生菌。Calebin A 可用于骨关节炎、阿尔茨海默病、2 型糖尿病、恶性外周神经鞘瘤及结直肠癌的相关研究。
土贝母苷甲
Tubeimoside I 是一种口服活性的 HSPD1 抑制剂。Tubeimoside I 能够抑制 NF-κB 和 MAPK，调节 eNOS-VEGF。Tubeimoside I 通过 Akt 介导通路诱导细胞保护性自噬 (Autophagy)。Tubeimoside I 抑制促炎细胞因子 (IL-6 和 IL-1β) 产生。Tubeimoside I 具有抗炎活性，能够促进血管生成，改善脓毒症症状。Tubeimoside I 主要用于炎症性疾病、各种癌症、脓毒症和缺血性疾病的研究。
Murrayafoline A (Standard) 是 Murrayafoline A (HY-W100287) 的分析标准品。本产品用于研究及分析应用。Murrayafoline A 是一种可以从 Murraya tetramera 中提取的咔唑类生物碱。Murrayafoline A 直接靶向特异性蛋白 1 (Sp1)，从而抑制 NF-κB 和 MAPK 信号通路。Murrayafoline A 在血小板衍生生长因子 (PDGF) 刺激的血管平
冬绿苷 (标准品)
Gaultherin (Standard) is the analytical standard for Gaultherin (HY-N1965). Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654).
土贝母苷甲 (标准品)
Tubeimoside I (Standard) 是 Tubeimoside I 的分析标准品。本产品用于研究及分析应用。Tubeimoside I 是一种口服活性的 HSPD1 抑制剂。Tubeimoside I 能够抑制 NF-κB 和 MAPK，调节 eNOS-VEGF。Tubeimoside I 通过 Akt 介导通路诱导细胞保护性自噬 (Autophagy)。Tubeimoside I 抑制促炎细胞因子 (IL-6 和 IL-1β) 产生。Tubeimoside I 具有抗炎活性，能够促进血管生成，改善脓毒症症状。Tubeimoside I 主要用于炎症性疾病、各种癌症、脓毒症和缺血性疾病的研究。
黄卡瓦胡椒素B
Flavokawain B (Flavokavain B) 是一种口服活性的查耳酮。Flavokawain B 可激活 caspase-9、-3 和 -8，切割 PARP。Flavokawain B 可下调 Bcl-2，同时增加 Bax 水平。Flavokawain B 可抑制 NF-κB、PI3K/Akt 和 MAPK 信号通路。Flavokawain B 具有凋亡 (Apoptotic) 作用。Flavokawain B 可抑制 MMP-9 和促进 ROS 生成。Flavokawain B 可抑制多种肿瘤和炎症。
Murrayafoline A 是一种可以从 Murraya tetramera 中提取的咔唑类生物碱。Murrayafoline A 直接靶向特异性蛋白 1 (Sp1)，从而抑制 NF-κB 和 MAPK 信号通路。Murrayafoline A 在血小板衍生生长因子 (PDGF) 刺激的血管平滑肌细胞中诱导 G0/G1 期阻滞。Murrayafoline A 通过促进细胞内 β-catenin 的降解减弱 Wnt/β-catenin 途径。Murrayafoline A 通过激活蛋白激酶 C 增强大鼠心室肌细胞的收缩和 L 型钙电流。Murrayafoline A 抑制体内 LPS (HY-D1056) 诱导的神经炎症。Murrayafoline A 可用于炎症、血管并发症和结肠癌研究。
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
MedchemExpress Validation 03
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
MedchemExpress Validation 04
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
MedchemExpress Validation
Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred
to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was
used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
![Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside](http://hg.y866.cn/biomolecule/lib/file/product_pic/hy-n5084.gif)
